According to a recent market study published by Growth Market Reports, titled, “Global Guanidine Market by type, by application, and by Region: Size, Share, Trends and Opportunity Analysis, 2018-2028”, the market was valued at US$ 343.3 Million in 2020 and is anticipated to grow at a growth rate of 2.9% by the year 2028.

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Guanidine is a compound with the formula HNC(NH2)2. It is a colorless solid that dissolves in polar solvents. It is a strong base that is used in the production of plastics and explosives. It is found in urine as a normal product of protein metabolism. A guanidine moiety appears in large organic molecules, including on the side chain of arginine. Guanidine is a nitrogenous analog of carbonic acid.

The C=O group in carbonic acid is replaced by a C=NH group, and each OH is replaced by an NH2 group. Guanidine is a crystalline compound of strong alkalinity formed by the oxidation of guanine. It is used in the manufacture of plastics and explosives, which was first isolated by Adolph Strecker via the degradation of guanine. It was first synthesized in 1861 by the oxidative degradation of an aromatic natural product, guanine, isolated from Peruvian guano.

Guanidine is of three types, namely, guanidine carbonate, guanidine hydrochloride, and guanidine carbonate. Guanidine carbonate is a widely used organic guanidine compound with molecular formula C3H12N6O3, and is widely utilized as raw material in manufacturing processes in end-user industries, including cosmetics, detergents, and textile.

Guanidine carbonate is a strong base, and is widely used as an intermediate in chemicals, cosmetics, and detergents as well as in microencapsulation processes. Guanidine carbonate forms a precursor for the production of guanidine hydroxide, which is further utilized as an active ingredient in several formulations used in chemical hair-relaxing treatments.

Key factors that are anticipated to fuel the demand for guanidine market during the forecast period are growing demand for guanidine in pharmaceutical industry for drug development, rising adoption of guanidine in cosmetics, and rising demand for guanidine in medical industry for treatment of muscle weaknesses is expected to drive the market. Conversely, stringent regulations by government and health hazards associated with working in chemical environment are likely to restrain the market. Growing usage of guanidine in textile industry for manufacturing of antibacterial fabrics is creating opportunities in the market.

As per Growth Market Reports industry analyst Sakshi Bhoyar, “The Global Guanidine Market is expected to witness substantial growth during the forecast period 2021-2028. Growing demand of guanidine in pharmaceuticals industry as guanidine is used in antibiotic drugs such as streptomycin, also trimethoprim (mainly used for urinary tract infections) and Chlorhexidine are guanidine derivatives used for antibiotic drugs which is expected to boost the guanidine market.

Rising demand of guanidine in cosmetic industry owing to
cosmetic industry has been the primary market for guanidine carbonate. Guanidine carbonates are mainly used as raw materials in the cosmetic industry. Cosmetics comprise a range of products that are used for face and body care or to enhance or change the appearance of the face or body.

These products include skin care, personal care, cosmetics, and fragrance. A vast array of cosmetics is available, ranging from shampoo to moisturizer to lipstick. Each sub-category of cosmetics has its own characteristics, however, the products are generally formulated using a mixture of chemical compounds derived from natural sources or created synthetically. Growing demand for cosmetic products is expected to increase the demand for guanidine, thereby promoting the growth of the guanidine market.

Applications of guanidine hydrochloride in the medical industry as an orally administered human drug are rising. Guanidine hydrochloride is used for the treatment of muscle weakness and easy fatigue caused by a rare disease known as the myasthenic syndrome of Eaton-Lambert, which is associated with small-cell carcinoma of the lung.

The precise action of the drug is not known; however, it apparently acts to enhance the release of acetylcholine and to slow the rates of depolarization and repolarization of muscle cell membranes. Guanidine hydrochloride is used as denaturation agent, as strong denaturants such as guanidinium hydrochloride are used in intact RNA isolation and guanidinium salts help disrupt cells, solubilize their components, and denature endogenous RNases simultaneously

The economy in APAC is mainly affected by the economic dynamics of countries such as China and India; however, with the increase in FDI in the developing economy of Southeast Asia, the current scenario is starting to change. Countries in Southeast Asia are registering strong growth, due to increased demand for detergents, chemicals, pharmaceuticals, and other products. Many festivals are celebrated in countries such as India and China, where a lot of fabrics are use. Increasing demand for clothes raises the demand for detergents, which is expected to eventually increase the demand for guanidine. "

COVID-19 has positively impacted on the market due to the consideration of guanidine as essential goods for pharmaceutical industry. COVID-19 had a positive impact on the market, due to increase in supply and demand for pharmaceutical industry. Rapid spread of coronavirus had a major impact on global markets, as major economies of the world are in lockdown due to the pandemic.

Hence, all the consumer markets started to show zero interest towards purchasing cosmetics goods; however, demand for essentials goods increased exponentially. In the lockdown, all essential goods and cargos are allowed to move around interstates, which are driving the demand for guanidine carbonate. The COVID-19 pandemic is expected to boost the growth of the market; however, the demand for guanidine in the pharmaceutical industry for production of drugs positively affected the market.

The Guanidine value chain includes activities such as strategy, product development, scoping, user documentation, marketing, implementation, training and certification, maintenance and support, licensing, and operation.

Key Takeaways from the Study

  • Key players operating in the Global Guanidine market include Borealis AG, Vihita Chem Private Limited., Sanwa Chemical CO. Ltd., Alzchem Group AG, Merck KGaA, Thermo Fisher Scientific Inc., MP BIOMEDICALS., Shizuishan Pengsheng Chemical Co., Ltd, NIPPON CARBIDE INDUSTRIES CO., INC., and Suvchem. These companies are considered as key manufacturers of guanidine market, based on their revenue, research & development (R&D) activities, presence, and supply chain management system hold a major market share of Global Guanidine market in year 2020.
  • Based on types, the market is classified into guanidine nitrate, guanidine hydrochloride, guanidine carbonate, and others. The guanidine nitrate segment is anticipated to expand substantially during the forecast period owing to the rising demand of guanidine nitrate in pesticide for agricultural use.
  • On the basis of applications, the market is segregated into pharmaceuticals, dye, and pesticides. The pharmaceutical segment is expected to grow considerably during the forecast period due to rapid growth of pharmaceutical industry and rising demand for guanidine in manufacturing of medicines.

Report Scope

Report Metric


Market Value in 2020

US$ 343.3Million

Market Growth Rate (from 2020 to 2028)

2.9 %

Historical Data

2018 & 2019

Base Year


Forecast Period

2021 - 2028

Units Considered

Value (US$ Million)

Market Segments

By Type, By Application, and By Region

Key Companies Profiled

Borealis AG, Vihita Chem Private Limited., Sanwa Chemical CO. Ltd., Alzchem Group AG, Merck KGaA, Thermo Fisher Scientific Inc., MP BIOMEDICALS., Shizuishan Pengsheng Chemical Co., Ltd, NIPPON CARBIDE INDUSTRIES CO.,INC., and Suvchem

Customization Scope

Report customization available on request

Pricing and Purchase Options

Avail tailor-made purchase options to meet your research requirements.

Target Audience

  • Supply-side: Manufacturers and distributors
  • Demand Side: Pharmaceutical Industry, Dye Industry, and Pesticide Industry
  • Regulatory Side: Concerned government authorities, and other regulatory bodies.