Two Photon Microscopy Market Outlook
The global two-photon microscopy market size was valued at USD 127.2 Mn in 2019 and is projected to reach USD 185.1 Mn by 2027, expanding at a CAGR of 5.2% during the forecast period, 2020-2027. Two-photon microscopy stated to as two-photon laser scanning microscopy, is an improvement of accuracy fluorescence microscopy.
In confocal or epifluorescent microscopy, a single photon of light at a specified wavelength causes the fluorophore to release light. In two-photon microscopy, the fluorophore can be activated by efficiently absorbing two-photons concurrently. In this case, each photon itself has a wavelength that is double the normal wavelength of excitation, and has half the energy level per photon.
Once the fluorophore consumes the two low-energy photons around the same moment, each adds half of the excitation energy required to communicate with the fluorophore, as it has been hit by a single photon of more energy and a short wavelength. Increasing emphasis on nanotechnology, favorable government policies, and funding are driving the growth of the two-photon microscopy market.
Furthermore, technical advances, such as super-resolution microscopy and high-throughput techniques, are boosting the demand for two-photon microscopy. Conversely, high cost of multiphoton microscopes and the regulatory duty limits the development and the demand for multiphoton microscopes.
Moreover, increasing funding, extended deadlines for clinical trial findings, rising number of R&D activities for two-photon microscopy is projected to fuel the market growth. Major advantages of this microscopy is that the near-simultaneous advent of two-photons is an exceedingly unusual occurrence; therefore, excitement of fluorescence is confined to a small plane of focus within the specimen.
This technique offers better images than conventional confocal microscopy, even in situations where relatively few fluorophores are involved and photons are released from the excited fluorophores located on the focal plane. Therefore, all the light that is produced can be stored. Fluorophores above and below the focal plane are not operated enough to create any fluorescent background.
Two Photon Microscopy Market Dynamics
Major established players dominate the market, thus creating hindrances for new players. The introduction of two-photon microscopy, helps companies cater to several consumers and increases their market presence. Opportunities for new players to enter the market are low due to high initial investment and strict regulation pertaining to two-photon microscopy manufacturing.
Less availability of raw materials due to pandemic and increased R&D for manufacturing of two-photon microscopes are expected to increase the bargaining power of suppliers. Buyers have access to refurbished products, as most of the two-photon microscopes and their accessories can be reused; therefore, the bargaining power of buyers is moderate.
The exact substitution of two-photon is currently unavailable in the market; however, other microscopic techniques such as confocal and three-photon microscopy techniques are being used by several end-users. This, reduces the growth of two-photon microscopy among conventional end-users. The software of two-photon microscopy is trending among end-users due to their highly efficient outcomes with the requirement of less efforts and manpower.
Rising Focus on Nanotechnology
Nanomaterials provide lightweight and efficient components for applications in the automobile and building industries. Nanotechnology in coatings makes surface products durable, water-resistant, and stain-resistant, thus providing options for high street fashion and high-end athletic equipment in the clothing industry.
Many high-performance electronic devices depend on nanotechnology, for example, Quantum Dot (QD) technology for LED displays and smartphones (QDs provide high quality and reliable color reproduction). Global investment in nanotechnology is expected to be equivalent to USD 4 trillion. Out of which China and the US together are spending more than USD 2 billion during the forecast period.
Growing emphasis on nanotechnology research, which is heavily financed by private enterprises and governments, facilitates the procurement of sophisticated automated microscopes by numerous research institutes. This, in turn, is projected to boost the two-photon microscopy market rapidly during the forecast period.
Increasing Application Areas of Two-photon Microscopy
Scientists have been improving microscopes ever since the devices were invented in the late sixteenth century, and have accelerated significantly over the past decade. The infrared excitation light which is used in the two-photon microscopy is not as much harmful to the biological samples; with UV-excitable fluorophores than those utilizing UV light.
Two-photon microscopy has allowed for a greater understanding of these processes within living cells. Technological advancements proven in current applications of the two-proton microscopy have led to faster imaging of embryos, comprising those of zebra fish and fruit flies while maintaining viability.
Each microscope technique involves a compromise. Many advances have been made using these microscopy tools. The two-photon microscopy is used in many industrial applications such as automotive, machinery, and water treatment. Hence, increasing application of two-photon microscopy is estimated to boost the market during the forecast period.
Two-Photon Microscopy Market Segment Insights
Products Segment Analysis
On the basis of products, the two-photon microscopy market is segmented into microscope, software, and accessories. The microscope segment is expected to hold a significant share of the market due to growing applications and high demand for technologically advanced magnification devices, while the accessories segment is projected to expand at a significant CAGR during the forecast period.
Types Segment Analysis
Based on types, the two-photon microscopy market is bifurcated into in vivo and in vitro. The in vitro segment is projected to constitute 57.9% share of the market by 2027 and is anticipated to expand at a CAGR of 5.3%, as it is commonly preferred for high incidence chronic and infectious diseases drug production.
Applications Segment Analysis
In terms of applications, the two-photon microscopy market is classified as material science, nanotechnology, life science, semiconductors, and others. The life science segment holds a major share of the market and is projected to expand at a substantial CAGR during the forecast period, as a majority of two-photon microscopy is utilized by this segment. The nanotechnology segment is expected to drive the demand for two-photon microscopy owing to the increasing research in nanomaterials during the forecast period.
Regional Analysis
In terms of regions, the global two-photon microscopy market has been fragmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America is a promising region for the market.
The market is this region constituted 42.0% share of the global market in 2020. The market in Asia Pacific is projected to expand at a CAGR of 5.7% due to the increase in government spending, rising awareness about two-photon microscopy, and growing consumer base in the region.
Key Benefits for Industry Participants & Stakeholders
- In-depth Analysis of the Global Two-Photon Microscopy Market
- Historical, Current and Projected Market Size in terms of Value
- Potential & Niche Segments and Regions Exhibiting Promising Growth Covered
- Industry Drivers, Restraints and Opportunities Covered in the Study
- Recent Industry Trends and Developments
- Competitive Landscape & Strategies of Key Players
- Neutral Perspective on Global Two-Photon Microscopy Market Performance
Segments
Product
- Microscope
- Software
- Accessories
Type
Application
- Material Science
- Nanotechnology
- Life Science
- Semiconductors
- Others
Region
- North America
- Latin America
- Brazil
- Mexico
- Rest of Latin America
- Europe
- Germany
- France
- Italy
- U.K.
- Spain
- Russia
- Rest of the Europe
- Asia Pacific
- China
- Japan
- South Korea
- India
- Australia
- South East Asia (SEA)
- Rest of Asia Pacific
- Middle East & Africa (MEA)
- Saudi Arabia
- South Africa
- UAE
- Rest of MEA
Key Market Players Profiled in the Report
- Bruker
- Femtonics Ltd.
- LaVision BioTec GmbH
- Leica Microsystems
- Nikon Instruments Inc.
- OLYMPUS CORPORATION
- ZEISS International
- Judges Scientific plc
- Sutter Instrument Company
Competitive Landscape
Key players in the market include Bruker, Leica Microsystems, Nikon Instruments Inc., OLYMPUS CORPORATION, and ZEISS International. They are considered as key manufacturers in this market based on their investments in R&D, segmental revenue, regional presence, and supply chain management system.
The players are adopting key strategies such as acquisition, and geographical expansion where potential opportunity for the two-photon microscopy is added in the company’s capacity.
- For instance, In November 2018, Bruker introduced next-generation wide-field, multi-photon microscope for opto-genetics. This New Ultima 2Pplus which delivers versatile and advanced 3d photo stimulation and full-field imaging for neurobiology.
- In September 2020, Nikon Instruments Inc. has announced the launch of NIS-Elements Clarify.ai, a new addition to Nikon’s on the rise suite of artificial intelligence tools for microscopy.
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