Protein Crystallization & Crystallography Market Size [2031]

Report Description

Protein Crystallization & Crystallography Market Outlook 2031

The global protein crystallization & crystallography market size was USD 1.59 Billion in 2022 and is likely to reach USD 3.65 Billion by 2031, expanding at a CAGR of 8.78% during 2023–2031. The market is propelled by the advancements in structural biology.

Growth of drug discovery and development is anticipated to boost the market during the assessment period. Protein crystallography is essential for drug discovery, as it helps in understanding the drug-protein interactions, thereby driving its adoption in the pharmaceutical industry. Furthermore, the biotechnology industry extensively relies on protein crystallography for drug development. As a result, the expansion of this industry is likely to fuel the market in the coming years.

• As per a survey published in August 2023, biopharmaceutical companies are responsible for approximately 40% of global drug sales. Numerous mid to small-size biotech companies that were known mostly to the insiders of the industry are becoming apparent through their work in drug development and discovery during the pandemic.

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Protein crystallization is a crucial component of academic and research programs, which further contributes to market expansion. Studies focused on determining the 3D structure of a wide range of proteins is likely to boost the market.

Moreover, there is a high demand for protein structure analysis for not only finding new potential treatments but also for creating personalized medicines and targeted therapies. This is expected to propel the market in the coming period.

The COVID-19 pandemic fueled the market owing to the shortage of medicines that could treat the infection during COVID-19 treatment. The health crisis during that period led to a high rate of mortality. Consequently, there was a surge in demand for groundbreaking treatments that could prove to be effective against the infection. This led to the major propulsion of the market.

Impact of Artificial Intelligence (AI) in Protein Crystallization & Crystallography Market

The use of artificial intelligence is likely to provide substantial propulsion to the protein crystallization & crystallography market. The use of artificial intelligence has transformed the field of protein crystallization & crystallography by simplifying the identification of protein structures.

By leveraging machine learning algorithms, it has become significantly easier to accurately identify diverse molecular structures. This has led to significant strides in the drug discovery and development of therapeutics. Consequently, the use of AI is expected to considerably propel the market in the coming years.

Protein Crystallization & Crystallography Market Dynamics

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Major Drivers

Surge in the requirement for protein therapeutics is expected to drive the market during the projection period. Protein therapies have become a vital part of the healthcare advancement. Owing to their specificity and low immunogenicity, these therapies are being extensively implemented to treat several types of severe ailments including cancer.

With the rise in the inclination of pharmaceutical and biopharmaceutical industries towards protein-based therapies, they are making substantial investments in research and development of such therapeutic practices. This is anticipated to propel the market in the coming years.

• In January 2022, Amgen collaborated with Generate Biomedicines to discover and create protein therapies. This has been done keeping in focus five clinical targets across various therapeutic areas and several domains.

Existing Restraints

Major complexity in protein crystallization is likely to hamper the market during the forecast period. Premium quality protein crystals are important for both X-ray formulation development and crystallography. It requires a highly pure and concentrated sample of protein.

The fluid portion of the solution evaporates, leaving behind protein crystals. This process is very complex to carry out and requires very precise mixing and measurement. This is projected to impede the market during the forecast period.

Emerging Opportunities

Advancements in technology are anticipated to provide substantial growth opportunities for the market. There have been substantial technological developments in the methods of crystallization in recent years methods, including cell-free protein crystallization.

The technology plays a significant role in the progress of structural biology by enabling the analysis of unstable proteins that can't be studied through standard techniques. These advancements promote the development of enhanced protein crystal treatments for various diseases including cancer and muscular dystrophy.

Scope of the Protein Crystallization & Crystallography Market Report

The market report includes an assessment of the market trends, segments, and regional markets. Overview and dynamics have also been included in the report.

Protein Crystallization & Crystallography Market Segment Insights

Technology Segment Analysis

Based on technology, the protein crystallization & crystallography market is divided into spectroscopy, X-ray crystallography, small-angle X-ray scattering, and cryo-electron microscopy. The x-ray crystallography segment is anticipated to capture the largest market share during the forecast period.

It is a technique used to determine the 3-dimensional, high-resolution molecules of proteins and has played a substantial role in advancing numerous scientific disciplines. Digital X-ray crystallography measures chemical bond types and types, atom sizes, atomic-scale differences, crystalline integrity, grain size, grain orientation, and others. As a result, its use has significantly increased in recent years and is likely to create lucrative prospects for the market.

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Product Segment Analysis

On the basis of product, the global market is segregated into instruments, consumables, and software & services. The consumables segment is anticipated to dominate the market revenue during the forecast period.

Consumables include kits, screens, reagents, and microplates, that support crystallization techniques. Protein crystallization kits provide an efficient screening technique to identify the ideal solubility conditions for protein crystallization. These kits contain chemicals required for quick screening to determine the optimal conditions for the crystallization of purified protein samples.

The software and services segment is anticipated to grow at a high CAGR during the forecast period. Software is used throughout the crystallization process, including analysis, design, dispensing, and image viewing. For example, the FORMULATRIX program ROCK MAKER enables the rapid creation of many screen assays for one or more proteins and assigns scores to aid in the comparison of collected images. This type of software capability is expected to drive segment growth over the forecast period.

End-user Segment Analysis

On the basis of end-user, the protein crystallization & crystallography market is segmented into research & government institutes, pharmaceutical & biotechnology companies, and others. The pharmaceutical & biotechnology companies segment is anticipated to register a robust growth rate during the forecast period as protein crystallography plays a crucial in drug design and discovery.

It produces precise 3-D protein structures that help understand disease mechanisms, create drugs effectively, and find therapeutic targets. Its success in developing transformative medicines such as HIV protease inhibitors and leukemia drug Gleevec. Consequently, this segment is anticipated to have major propulsion in the years to come.

• In October 2022, Tokyo Tech, one of the leading key market players, introduced direct protein crystallization. It is a new technology for cell-free protein crystallization and opens the possibility of studying unstable proteins.

Regional Outlook

In terms of region, the global protein crystallization & crystallography market is classified as Asia Pacific, North America, Latin America, Europe, and Middle East & Africa. North America is expected to dominate the market during the projection period due to the advanced medical infrastructure and the presence of several prominent market players in this region.

Surge in technological advancements and the rise in R&D activities have led to the major development of pharmaceutical and biopharmaceutical companies are anticipated to create lucrative opportunities for the market in this region.

The market in Asia Pacific is projected to witness considerable propulsion owing to the expansion of the pharmaceutical industry and industrial expansion in economies such as India and China. Other factors such as the rise in the overall population, increase in geriatric population in proportion, and increase in disposable income play a considerable role in strengthening the market.

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