The Global Patient Derived Xenograft (PDX) Models Market was valued at USD 113.5 Million in 2019 and is anticipated to reach 283.3 Million by 2027, expanding at a CAGR of 14.5% during the forecast period. Patient-derived xenografts (PDX) are models of cancer in which the cells from a patient’s tumor are inserted into an immune deficient or humanized mouse. PDX models simulate that human tumor biology is allowing for natural cancer progression and offers translational research for calculating the desired result. Patient-derived xenograft (PDX) mouse models includes the insertion of fresh human tumor samples directly into the immune-deficient mice by surgery. Xenograft animal models are required for testing the effectiveness of medicines and are mostly required in drug advancement for cancer, diabetes, infections, etc.
Gene expression in tumors is maintained by sequential path of tumors from mouse to mouse. These models support research for tumor biology and pharmacology deprived of manual influence of cell cultures and are usually used in modified cancer therapy, drug enlargement and clinical tests. PDX models show advanced predictive values for clinical results than cell line‑derived xenograft models and hereditarily engineered mouse models.
The market is driven by factors such as Rising governments support for pharmaceutical and biotechnology industries, growing demand for personalized medicines, increasing R&D activities by pharmaceutical and biotechnology companies, surging number of preclinical studies for developing anti-cancer drugs for solid tumors. Conversely, high cost of personalized PDX models, implementation of stringent guidelines on the use of animal models in cancer research. Rising demand for humanized PDX models is one the major factors anticipated to create lucrative opportunities in the market.
Based on types, the Global Patient Derived Xenograft (PDX) Models Market is fragmented into mice models and rat models. Mice models segment is anticipated to hold the largest market share during the forecast period. Ease of procurement, manipulation, and the minimum facilities required for keeping mice models under observation in comparison to rats is driving the PDX models market. Rising development of biotechnological goods and new medical devices is expected to boost the global patient-derived xenograft (PDX) market. New competitive market players bringing innovative healthcare solutions is anticipated to grow the preclinical testing market, which is expected to increase the demand for rat models. Introduction of immunodeficient rats drives the use of rat models in the PDX models market. Rat models segment is anticipated to boost at a substantial growth rate during the forecast period. Factors which drives this market consists of the larger size of rats, which enhances surgical manipulation.
On the basis of tumor types, the global patient-derived xenografts (PDX) models market is segmented into gynecological tumor models, gastrointestinal tumor models, urological tumor models, respiratory tumor models, hematological tumor models, and other tumor models. The gastrointestinal tumor models segment is anticipated to dominate the global patient-derived xenografts (PDX) models market, due to rising number of gastrointestinal tumor models and growing gastrointestinal tumor research in academic & research institutions and contract research organizations (CROs). The respiratory tumor model segment is expected to grow at the highest rate during the forecast period. Factors attributing to the growth of the segment includes increasing research activities in the oncology field and growing focus of competitive market players on generating lung cancer PDX models, due to increasing number of cancer cases. Funds for companies involved in cancer research are anticipated to grow at a rapid pace during forecast period for the global patient-derived xenografts (PDX) models market.
Based on applications, the global patient-derived xenografts (PDX) models market is fragmented into preclinical drug development, biomarker analysis, and basic cancer research. Preclinical drug development segment is anticipated to reach the maximum growth rate in the PDX models market during the forecast period. Compound annual growth rate of this segment is attributed to increasing number of clinical tests. The basic cancer research and preclinical drug development segment accounts for a large market share of the global PDX models market. The segment is important, due to rising number of research activities in the oncology drug research field. The basic cancer research disease segment is anticipated to grow at a substantial rate, due to increasing adoption of PDX models for basic cancer research. Basic cancer research is the characterization of cancer biology and exploring mechanisms that are involved for prediction or having a knowledge of cancer.
Based on end-users, the global patient-derived xenograft (PDX) models is fragmented into Pharmaceutical & Biotechnology Companies, Contract Research Organizations (CROs), and Academic & Research Institutions. The academic & research organizations segment dominates the market, as the usage of PDX models is growing for basic cancer research and characterization of cancer biology, tumorigenesis, and metastasis. The contract research organizations segment is anticipated to grow at a high CAGR during the forecast period. Market growth rate in this segment are attributed to rising number of pharmaceutical companies, which outsource preclinical studies to CROs. The pharmaceutical and biotechnology companies segment is growing at a rapid pace, owing to the boost provided by the ongoing pandemic. Market players are focusing on developing new and efficient products to cater to the growing needs of the market. The segment is predicted to grow at a substantial rate.
Based on regions, the global Patient Derived Xenograft (PDX) Models market is segregated into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America accounts for a major share of the market, followed by Europe. The market in North America is projected to expand at a significant CAGR during the forecast period, owing to increasing preclinical activities by CROs and pharmaceutical companies and rapid growth in onco-immunology research are some of the factors driving the market in North America. Moreover, the market in Asia Pacific is expected to grow due to rising prevalence of cancer and increasing government expenditure on pharmaceutical R&D. It is also estimated to grow at the highest CAGR in the PDX models market during the forecast period, mainly owing to factors such as increasing trend of outsourcing drug discovery services, and growing life sciences research.
Some frequently asked quetions about this report!
Additional company profiles can be provided on request
According to this Growth Market Reports, the Patient Derived Xenograft (PDX) Models market is likely to register a CAGR of 14.5% during forecast period 2020-2027, with an anticipated valuation of USD 283.3 million by the end of the 2027.
In addition to market size (in US$ Million), Company Market Share (in % for base year 2019), Regulatory Landscape, Technology Landscape, Patent Analysis, Consumer Survey, and Pipeline/Clinical Trial Analysis.
Rising governments support for pharmaceutical and biotechnology industries, growing demand for personalized medicines, increasing R&D activities by pharmaceutical and biotechnology companies, and surging number of preclinical studies for developing anti-cancer drugs for solid tumors are the factors expected to drive the market growth during forecast period.
Usage of PDX model in preclinical drug development, biomarker analysis, and basic cancer research studies are the major applications of the Patient Derived Xenograft (PDX) Models.
Factors such as competitive strength and market positioning are key areas considered while selecting top companies to be profiled.
The market is expected to show decline of -3.2% in growth market between 2019 and 2020 owing to the COVID 19 pandemic effect on the Patient Derived Xenograft (PDX) Models market.
The base year considered for the Global Patient Derived Xenograft (PDX) Models market report is 2019. The complete analysis period is 2017 to 2027, wherein, 2017, and 2018 are the historic years, and the forecast is provided from 2020 to 2027.
Factors such as Surgical Treatment, Healthcare Expenditure, Technological Advancements, Export & Import Scenario, Price of Drugs, and GDP are analyzed in the final report.
Major manufactures include, THE JACKSON LABORATORY, WuXi AppTec, Envigo, Oncodesign, Charles River Laboratories, Explora BioLabs, Champions Oncology, Inc. and others.
Some other reports from this category!