The global organoids and spheroids market size was USD 405.8 Mn in 2022 and is likely to reach USD 2100 Mn by 2031, expanding at a CAGR of 22.6% during 2023–2031. The market growth is attributed to the increase in the demand for cell therapy and tissue engineering.
Organoids and spheroids are 3D cell culture units that are cultured with various techniques. These 3D cell culture units are majorly used as building blocks in the generation of complex organs and tissues. 3D spheroids are considered to be essential aspects in the field of regenerative medicine science and tissue engineering. Organoids are used for therapeutic purposes such as insulin production, misfiring stem cells, and examining brain neurons.
With the help of organoids, researchers study several processes that happen in the body. Organoids and spheroids have a similar structure to original organs and carry human genetic information. Organoids are replicas of human organs such as lungs, intestines, kidney, brain, stomachs, and livers. This type of organoid model shows phenotypic traits of the organ they are grown from and exhibits self-regulation potential.
Organoids are derived from embryonic or adult stem cells. These cells divide and produce various types of cells. Organoids are complex clusters while spheroids are well-designed cell aggregates used as engineered cancer models. Moreover, spheroids are derived from mammary glands, tumor tissue, hepatocytes, and embryoid bodies.
Spheroids have importance in cancer treatment as it mimics the main therapeutics resistance patterns of solid tumors. It recapitulates the basic 3D structure of tumors, such as central necrosis, multicellular structure, and proliferation gradients depending on tumor type. This 3D cell culture is produced in vitro cultures in optimum lab scenarios and used in various applications to study the biological process on a cellular level.
The COVID-19 pandemic has moderately affected biotechnology and pharmaceutical companies. Moreover, increased R&D for developing regenerative medicines for treating COVID-19 patients and rapid development in stem cell therapy research propel the market growth. For instance, scientists have developed miniature lungs to study the mechanism of the entry of SARS-CoV-2. Organoids aid in the study of the defense mechanism of tissue against SARC-CoV-2. This has a great impact on vaccine development.
Organoids and Spheroids Market Dynamics
Major Drivers
Rising demand for organoid cultures in the drug development process is anticipated to fuel the market growth during the forecast period. Organoid technology has applications in genetic mutation, gene assessment, and tumor modelling. Moreover, organoid 3D cell cultures are used in cancer research as cancer prevalence is rising. Cancer research is rising due to the rising investments in R&D activities.
Exiting Restraints
Complexity in the reconstruction of complex in vivo cellular diversity and signaling of organs or tumors is expected to hamper the market. In addition, high cost of implementation is anticipated to hinder the market during the forecast period.
Emerging Opportunities
Rapid technological developments in 3D spheroid technology are expected to fuel market growth. For instance, AMS Biotechnology (AMSBIO) introduced Cultrex Organoid Progenitor Cells, which can be optimized by the use of different sets of extracellular matrices. Researchers are able to direct cell activity by controlling the culture microenvironment. Cultrex spheroid proliferation/viability and invasion assays provided by the company stimulate the development of cohesive spheroids even in low adhesion environments.
Organoids-on-a-chip technology and the development of high throughput Organoids-on-a-chip technology propel the use of patient-derived organoids in clinical practice and facilitate therapeutic decision-making. Organoids-on-a-chip technology is microfabricated cell culture devices. Organ chips have microfluidic channels lined by living human organ-specific cells. The construction of any organ-on-a-chip system is guided by design principles based on a reductionist analysis of its target organ.
Scope of the Organoids and Spheroids Market Report
The market report includes an assessment of the market trends, segments, and regional markets. Overview and dynamics have also been included in the report.
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Attributes
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Details
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Report Title
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Organoids and Spheroids Market - Global Industry Analysis, Growth, Share, Size, Trends, and Forecast
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Base Year
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2022
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Historic Data
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2016–2021
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Forecast Period
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2023–2031
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Segmentation
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Method (Spinning Bioreactor, Extracellular Matrix Scaffold, Hanging Drop, Magnetic Levitation, Low Adherent Culture Plate, and Others), Application (Developmental Biology, Personalized Medicine, Regenerative Medicine, Disease Pathology Studies, and Drug Toxicity & Efficacy Testing), and End-user (Biotechnology & Pharmaceutical Industries, Academic & Research Institutes, and Hospitals & Diagnostic Centers)
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Regional Scope
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Asia Pacific, North America, Latin America, Europe, and Middle East & Africa
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Report Coverage
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Company Share, Market Analysis and Size, Competitive Landscape, Growth Factors, Market Trends, and Revenue Forecast
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Key Players Covered in the Report
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3D Biotek LLC; 3D Biomatrix; AMS Biotechnology Limited; ATCC, Cellesce Ltd.; Corning Incorporated; Greiner Bio-One; HubrechtOrganoid Technology; InSphero/Perkin Elmer; Kuraray; Lonza; Merck KGaA; Prellis Biologics; STEMCELL Technologies Inc.; and Thermo Fisher Scientific, Inc.
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Organoids and Spheroids Market Segment Insights
On the basis of method, the organoids and spheroids market is segmented into spinning bioreactor, extracellular matrix scaffold, hanging drop, magnetic levitation, low adherent culture plate, and others. The extracellular matrix scaffold segment is anticipated to register a robust growth rate in the coming years as it is widely used for the large production of organoids and spheroids. The cost-effectiveness of this method and the ability to produce organoids and spheroids in less time are likely to accelerate segment growth.
Based on application, the market is divided into developmental biology, personalized medicine, regenerative medicine, disease pathology studies, and drug toxicity & efficacy testing. The biology development segment constituted a significant share of the market. Organoid and spheroid culture systems are used for biological development.
The regenerative medicine segment is projected to constitute a large market share during the forecast period, as organoid and spheroid transplantation from adult stem cells helps to replace diseased tissue or organ.
On the basis of end-user, the market is segregated into biotechnology & pharmaceutical industries, academic & research institutes, and hospitals & diagnostic centers. The biotechnology and pharmaceutical industries segment is projected to expand at a significant pace during the forecast period. Potential organoid and spheroid clinical applications have encouraged pharmaceutical start-ups to enter this market. Furthermore, the high consumption of organoids and spheroids in pre-clinical drug discovery by pharmacists is expected to boost segment growth.
In terms of region, the global market is classified as Asia Pacific, North America, Latin America, Europe, and Middle East & Africa. North America is expected to dominate the market during the forecast period, due to an increase in organoid-based models of biotechnology and spheroid research in the US and Canada. Moreover, the presence of key players including Thermo Fisher Scientific, Corning, and PerkinElmer is anticipated to propel market growth considerably.
Advanced technology is employed to overcome limitations faced by the 2D cell culture platforms. 3D spheroids provide a suitable environment that mimics the properties of human tissue structures. Three-dimensional cell cultures serve better models and represent in vivo physiological conditions closely. 3D cell cultures are prevalent and enable cell-to-cell communication.
A study conducted by the American Association for the Study of Liver Diseases (AASLD) on the advent of organoid medicine in hepatology was supported by AASLD Foundation (Pinnacle Research Award); North American Society of Gastroenterology Hepatology and Nutrition (NASPGHAN) Foundation (George Ferry Young Investigator Award); and Cincinnati Children’s Research Foundation (Procter Scholar Award).
For instance, a February 2020 study conducted by the American Association for the Study of Liver Diseases (AASLD) regarding the advent of organoid medicine in hepatology was supported by AASLD Foundation (Pinnacle Research Award); North American Society of Gastroenterology Hepatology and Nutrition (NASPGHAN) Foundation (George Ferry Young Investigator Award); and Cincinnati Children’s Research Foundation (Procter Scholar Award).
The market in Asia Pacific is anticipated to expand at a substantial pace during the forecast period, due to the rise in partnerships among key market players and constant developments in the field of stem cell research. The market growth is enhancing, due to the increasing partnerships in the market. For instance, Nichirei Biosciences and UPM Biomedicals partnered together to offer UPM culture products in Japan in March 2020. This development enhanced the availability of natural hydrogels for organoid and spheroid culture
Segments
The global organoids and spheroids market has been segmented on the basis of
Method
- Spinning Bioreactor
- Extracellular Matrix Scaffold
- Hanging Drop
- Magnetic Levitation
- Low Adherent Culture Plate
- Others
Application
- Developmental Biology
- Personalized Medicine
- Regenerative Medicine
- Disease Pathology Studies
- Drug Toxicity & Efficacy Testing
End-user
- Biotechnology & Pharmaceutical Industries
- Academic & Research Institutes
- Hospitals & Diagnostic Centers
Region
- Asia Pacific
- North America
- Latin America
- Europe
- Middle East & Africa
Key Players
- 3D Biotek LLC
- 3D Biomatrix
- AMS Biotechnology Limited
- ATCC, Cellesce Ltd.
- Corning Incorporated
- Greiner Bio-One
- HubrechtOrganoid Technology
- InSphero/Perkin Elmer
- Kuraray
- Lonza
- Merck KGaA
- Prellis Biologics
- STEMCELL Technologies Inc.
- Thermo Fisher Scientific, Inc.
Competitive Landscape
Key players competing in the global organoids and spheroids market are 3D Biotek LLC; 3D Biomatrix; AMS Biotechnology Limited; ATCC, Cellesce Ltd.; Corning Incorporated; Greiner Bio-One; HubrechtOrganoid Technology; InSphero/Perkin Elmer; Kuraray; Lonza; Merck KGaA; Prellis Biologics; STEMCELL Technologies Inc.; and Thermo Fisher Scientific, Inc.
Key players are actively engaged in R&D programs and aim at the expansion of manufacturing units to expand their consumer base and increase their product portfolio. For instance, Perkin Elmer is a leading company based in the United States, that offers a wide portfolio of platforms for handling, detection, and analysis of spheroids.
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