Non-Invasive Prenatal Testing market

Non-invasive Prenatal Testing Market by Gestation Periods (0-12 Weeks, 13-24 Weeks, and 25-36 Weeks), Risk Types (High & Average Risk and Low Risk), Methods (Ultrasound Detection, Biochemical Screening Tests, and Cell-free DNA in Maternal Plasma Tests), Technology (NGS, Array Technology, PCR, and Others), Products (Consumables & Reagents and Instruments), End-users (Hospitals & Clinics and Diagnostic Laboratories), and Regions (Asia Pacific, North America, Latin America, Europe, and Middle East & Africa) - Global Industry Analysis, Growth, Share, Size, Trends, and Forecast 2021 – 2028

  • Report ID: HC-1229
  • Author: Growth Market Reports
  • Rating: 4.8
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  • No. Of Pages: 155
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The global non-invasive prenatal testing market size was valued at USD 2.83 billion in 2020 and is anticipated to expand at a CAGR of 10.9 % during the forecast period, 2021 – 2028. The growth of the market is attributed to the increasing incidence of chromosomal abnormalities coupled with growing product usage in new applications. Furthermore, advancements in existing tests in terms of advanced functions, advanced chemistry, and bioinformatics research are other key factors boosting the market. One of the main guiding forces of the market is the expansion of reimbursement plans for average and low-risk pregnancies.

Non-invasive Prenatal Testing Market Key Takeaways

Non-invasive prenatal testing (NIPT) is a method of determining the level of risks that the fetus might carry with certain genetic abnormalities after they are born. It analyzes small fragments of DNA circulating in a pregnant woman’s blood. Genes and chromosomes can sometimes mutate, putting an unborn child at risk for genetic defects. Trisomy 21 is one of the most common chromosomal anomalies, according to an article written by the Children's Hospital of Philadelphia, affecting about 5000 babies per year in the US.

To diagnose the possibility of fetal aneuploidy, NIPT analyzes the cell-free fetal DNA (cfDNA) found in a sample of maternal blood. Unlike other invasive treatments such as amniocentesis and chorionic villus sampling (CVS), these non-invasive tests are less costly and very effective in determining the same, which act as key driving factor for NIPT testing.

Market Trends, Drivers, Restraints, and Opportunities

  • Increasing number of high maternal age mothers, which results to higher risk of genetic disorders in babies because of the improper chromosomal division. This is expected to boost the market.
  • Growing R&D activities from several firms towards the advancement of cutting-edge screening technology that are extremely efficient and effective in the early identification of genetic disorders in babies. This acts as a major driving factor for the market.
  • High cost of these tests and lack of the healthcare facilities in many developing countries are expected to restrict the NIPT market's development.
  • Rising governments’ efforts and policies to improve healthcare infrastructure in the coming years, from emerging economies such as China, India, Brazil, and Mexico are expected to provide major growth opportunities for market players.

Scope of the Report

The report on the global non-invasive prenatal testing market includes an assessment of the market, trends, segments, and regional markets. Overview and dynamics have also been included in the report.

Attributes

Details

Report Title

Non-Invasive Prenatal Testing market - Global Industry Analysis, Growth, Share, Size, Trends, and Forecast

Base Year

2020

Historic Data

2018–2019

Forecast Period

2021–2028

Segmentation

Gestation Periods (0-12 Weeks, 13-24 Weeks, and 25-36 Weeks), Risk Types (High & Average Risk and Low Risk), Methods (Ultrasound Detection, Biochemical Screening Tests, and Cell-free DNA in Maternal Plasma Tests), Technology (NGS, Array Technology, PCR, and Others), Products (Consumables & Reagents and Instruments), End-users (Hospitals & Clinics and Diagnostic Laboratories)

Regional Scope

Asia Pacific, North America, Latin America, Europe, and Middle East & Africa

Report Coverage

Company Share, Market Analysis and Size, Competitive Landscape, Growth Factors, and Trends, and Revenue Forecast

Key Players Covered in the Report

Genesis Genetics; Natera, Inc.; Centogene N.V.; Illumina, Inc.; Eurofins LifeCodexx GmbH; MedGenome Labs Ltd.; F. Hoffmann-La Roche Ltd.; Myriad Women’s Health, Inc.; Progenity, Inc.; Qiagen; Laboratory Corp. of America Holdings; and Quest Diagnostics, Inc.


Global Non-Invasive Prenatal Testing Market Segment Insights

13 to 24 weeks segment accounted for a high revenue share
Based on gestation periods, the global non-invasive prenatal testing market is divided into 0-12 weeks, 13-24 weeks, and 25-36 weeks. The 13-24 weeks segment accounted for a key share of the market in terms of revenue in 2020 and is expected to register a substantial CAGR during the forecast period. The growth of the segment is due to wide adoption of the testing in these particular weeks as most of the non-invasive prenatal diagnosis occurs in the second trimester of pregnancy. These procedures also include significant secondary tests including ultrasound and alpha-fetoprotein serum screening. To create a more precise and effective NIPT, some companies are focusing on the study of cffDNA in a sample of maternal blood obtained in the first trimester.

High & average risk segment to constitute a large market share
On the basis of risk types, the market is bifurcated into high & average risk and low risk. The high & average risk segment is projected to constitute a large share of the market in the coming years owing to the extensive use of these tests in high-risk conditions for patients aged 35 and above. Moreover, the segment growth can be attributed to the availability of favorable payer reimbursement in this sector as well as rising knowledge regarding the prevention of chromosomal anomalies including Down syndrome. On the other hand, the low-risk segment is expected to grow at a rapid rate during the forecast period. Government support, such as budget allocation for average-risk births, is projected to be a positive factor for the segment growth.

Cell-free DNA-based segment to generate a considerable revenue share
Based on methods, the global non-invasive prenatal testing market is segmented into ultrasound detection, biochemical screening tests, and cell-free DNA in maternal plasma tests. The cell-free DNA-based NIPT segment is projected to generate a considerable revenue share of nearly 43.6% in 2020. The growth of the segment is attributed to the wide use of Cell-free DNA in prenatal treatment to predict the likelihood of genetic disorders through various genetic analyses. Several research projects are being conducted to improve the use of the tests available from this segment. Meanwhile, the ultrasound detection segment is anticipated to hold a large market share in the coming years due to the wide adoption of the testing during pregnancy. Ultrasound detection is used in combination with the Cell-free DNA-based NIPT test, resulting in a lower market share for this segment. The test, on the other hand, serves as a basis for additional fetal monitoring to detect anomalies.

Non-invasive Prenatal Testing Market By Methods

NGS segment dominated the market
In terms of technology, the market is segmented into NGS, array technology, PCR, and others. The NGS segment dominated the market in 2020 and is expected to continue its trend in the coming years. The growth of the segment is attributed to the usage of NGS technology, including targeted genome sequencing, whole-genome sequencing, and whole-exome sequencing, for prenatal cfDNA testing. Whole-genome sequencing has been shown to have benefits over other methods including a reduced failure rate. In terms of performance, affordability, adoption, and technology, NGS technology is unmatched. As a result, NGS has become increasingly popular in this market. Several end users, however, have reported difficulties interpreting results while using NGS technology. As a result, array-based experiments have become more feasible for these users.

Consumables & reagents segment accounted for a major share
Based on product, the global non-invasive prenatal testing market is bifurcated into consumables & reagents and instruments. The consumables & reagents segment accounted for a major revenue share in 2020 and is projected to grow at a significant rate in the coming years. The growth of the segment is attributed to the widespread acceptance of NGS-based prenatal tests, which involve different reagents and assays to operate the sequencing procedure. The availability of a large number of suppliers who have solutions for isolating cell-free DNA is also propelling the segment forward. The instruments market, on the other hand, is projected to grow at a fast rate from 2021 to 2028, owing to instrument manufacturers' ongoing efforts to build advanced platforms. For example, PerkinElmer, Inc. provides the Vanadis NIPT System, an automated instrument that overcomes the cost, complexity, and capability limitations of other NIPT technologies for aneuploidy screening.

Non-invasive Prenatal Testing Market By Products

Diagnostic laboratories segment dominated the market
On the basis of end-users, the market is bifurcated into hospitals & clinics and diagnostic laboratories. The diagnostic laboratories segment dominated the market in 2020 and is expected to register a robust CAGR during the forecast period. The growth of the segment is attributed to the key players such as Illumina, which are outsourcing their sample processing to Illumina CLIA labs when in-house facilities are not sufficient. In addition, laboratories performing NIPT research throughout the US operate in accordance with quality-assurance requirements to ensure test quality and reproducibility.

North America is a dominant market
In terms of regions, the market is classified as Asia Pacific, North America, Latin America, Europe, and Middle East & Africa. North America held a dominant share in terms of revenue share in 2020, which is followed by Europe. The recent incorporation of NIPT in large insurance companies' business policies is expected to fuel market growth in the US. In June 2019, Illumina secured an infringement suit involving NIPT against Roche's Ariosa Diagnostics (Roche). The market in Asia Pacific is expected to be a fast-growing regional market owing to the increasing involvement of companies like BGI in China, which is a major player in the NIPT industry, is expected to propel the market growth.

1. Executive Summary
2. Assumptions and Acronyms Used
3. Research Methodology
4. Non-Invasive Prenatal Testing Market Overview
  4.1. Introduction
     4.1.1. Market Taxonomy
     4.1.2. Market Definition
  4.2. Macro-Economic Factors
     4.2.1. Industry Outlook
  4.3. Non-Invasive Prenatal Testing Market Dynamics
     4.3.1. Market Drivers
     4.3.2. Market Restraints
     4.3.3. Opportunity
     4.3.4. Market Trends
  4.4. Non-Invasive Prenatal Testing Market - Supply Chain
  4.5. Global Non-Invasive Prenatal Testing Market Forecast
     4.5.1. Non-Invasive Prenatal Testing Market Size (US$ Mn) and Y-o-Y Growth
     4.5.2. Non-Invasive Prenatal Testing Market Size (000’ Units) and Y-o-Y Growth
     4.5.3. Non-Invasive Prenatal Testing Market Absolute $ Opportunity
5. Global Non-Invasive Prenatal Testing Market Analysis and Forecast by End Users
  5.1. Market Trends
  5.2. Introduction
     5.2.1. Basis Point Share (BPS) Analysis by End Users
     5.2.2. Y-o-Y Growth Projections by End Users
  5.3. Non-Invasive Prenatal Testing Market Size and Volume Forecast by End Users
     5.3.1. Hospitals & Clinics Diagnostic Laboratories
  5.4. Absolute $ Opportunity Assessment by End Users
  5.5. Market Attractiveness/Growth Potential Analysis by End Users
6. Global Non-Invasive Prenatal Testing Market Analysis and Forecast by Region
  6.1. Market Trends
  6.2. Introduction
     6.2.1. Basis Point Share (BPS) Analysis by Region
     6.2.2. Y-o-Y Growth Projections by Region
  6.3. Non-Invasive Prenatal Testing Market Size and Volume Forecast by Region
     6.3.1. North America
     6.3.2. Latin America
     6.3.3. Europe
     6.3.4. Asia Pacific
     6.3.5. Middle East and Africa (MEA)
  6.4. Absolute $ Opportunity Assessment by Region
  6.5. Market Attractiveness/Growth Potential Analysis by Region
  6.6. Global Non-Invasive Prenatal Testing Demand Share Forecast, 2019-2026
7. North America Non-Invasive Prenatal Testing Market Analysis and Forecast
  7.1. Introduction
     7.1.1. Basis Point Share (BPS) Analysis by Country
     7.1.2. Y-o-Y Growth Projections by Country
  7.2. North America Non-Invasive Prenatal Testing Market Size and Volume Forecast by Country
     7.2.1. U.S.
     7.2.2. Canada
  7.3. Absolute $ Opportunity Assessment by Country
  7.4. North America Non-Invasive Prenatal Testing Market Size and Volume Forecast by End Users
     7.4.1. Hospitals & Clinics Diagnostic Laboratories
  7.5. Basis Point Share (BPS) Analysis by End Users
  7.6. Y-o-Y Growth Projections by End Users
  7.7. Market Attractiveness/Growth Potential Analysis
     7.7.1. By Country
     7.7.2. By Product Type
     7.7.3. By Application
  7.8. North America Non-Invasive Prenatal Testing Demand Share Forecast, 2019-2026
8. Latin America Non-Invasive Prenatal Testing Market Analysis and Forecast
  8.1. Introduction
     8.1.1. Basis Point Share (BPS) Analysis by Country
     8.1.2. Y-o-Y Growth Projections by Country
     8.1.3. Latin America Average Pricing Analysis
  8.2. Latin America Non-Invasive Prenatal Testing Market Size and Volume Forecast by Country
      8.2.1. Brazil
      8.2.2. Mexico
      8.2.3. Rest of Latin America
   8.3. Absolute $ Opportunity Assessment by Country
  8.4. Latin America Non-Invasive Prenatal Testing Market Size and Volume Forecast by End Users
     8.4.1. Hospitals & Clinics Diagnostic Laboratories
  8.5. Basis Point Share (BPS) Analysis by End Users
  8.6. Y-o-Y Growth Projections by End Users
  8.7. Market Attractiveness/Growth Potential Analysis
     8.7.1. By Country
     8.7.2. By Product Type
     8.7.3. By Application
  8.8. Latin America Non-Invasive Prenatal Testing Demand Share Forecast, 2019-2026
9. Europe Non-Invasive Prenatal Testing Market Analysis and Forecast
  9.1. Introduction
     9.1.1. Basis Point Share (BPS) Analysis by Country
     9.1.2. Y-o-Y Growth Projections by Country
     9.1.3. Europe Average Pricing Analysis
  9.2. Europe Non-Invasive Prenatal Testing Market Size and Volume Forecast by Country
     9.2.1. Germany
     9.2.2. France
     9.2.3. Italy
     9.2.4. U.K.
     9.2.5. Spain
     9.2.6. Russia
     9.2.7. Rest of Europe
  9.3. Absolute $ Opportunity Assessment by Country
  9.4. Europe Non-Invasive Prenatal Testing Market Size and Volume Forecast by End Users
     9.4.1. Hospitals & Clinics Diagnostic Laboratories
  9.5. Basis Point Share (BPS) Analysis by End Users
  9.6. Y-o-Y Growth Projections by End Users
  9.7. Market Attractiveness/Growth Potential Analysis
     9.7.1. By Country
     9.7.2. By Product Type
     9.7.3. By Application
  9.8. Europe Non-Invasive Prenatal Testing Demand Share Forecast, 2019-2026
10. Asia Pacific Non-Invasive Prenatal Testing Market Analysis and Forecast
  10.1. Introduction
     10.1.1. Basis Point Share (BPS) Analysis by Country
     10.1.2. Y-o-Y Growth Projections by Country
     10.1.3. Asia Pacific Average Pricing Analysis
  10.2. Asia Pacific Non-Invasive Prenatal Testing Market Size and Volume Forecast by Country
     10.2.1. China
     10.2.2. Japan
     10.2.3. South Korea
     10.2.4. India
     10.2.5. Australia
     10.2.6. Rest of Asia Pacific (APAC)
  10.3. Absolute $ Opportunity Assessment by Country
  10.4. Asia Pacific Non-Invasive Prenatal Testing Market Size and Volume Forecast by End Users
     10.4.1. Hospitals & Clinics Diagnostic Laboratories
  10.5. Basis Point Share (BPS) Analysis by End Users
  10.6. Y-o-Y Growth Projections by End Users
  10.7. Market Attractiveness/Growth Potential Analysis
     10.7.1. By Country
     10.7.2. By Product Type
     10.7.3. By Application
  10.8. Asia Pacific Non-Invasive Prenatal Testing Demand Share Forecast, 2019-2026
11. Middle East & Africa Non-Invasive Prenatal Testing Market Analysis and Forecast
  11.1. Introduction
     11.1.1. Basis Point Share (BPS) Analysis by Country
     11.1.2. Y-o-Y Growth Projections by Country
     11.1.3. Middle East & Africa Average Pricing Analysis
  11.2. Middle East & Africa Non-Invasive Prenatal Testing Market Size and Volume Forecast by Country
     11.2.1. Saudi Arabia
     11.2.2. South Africa
     11.2.3. UAE
     11.2.4. Rest of Middle East & Africa (MEA)
  11.3. Absolute $ Opportunity Assessment by Country
  11.4. Middle East & Africa Non-Invasive Prenatal Testing Market Size and Volume Forecast by End Users
     11.4.1. Hospitals & Clinics Diagnostic Laboratories
  11.5. Basis Point Share (BPS) Analysis by End Users
  11.6. Y-o-Y Growth Projections by End Users
  11.7. Market Attractiveness/Growth Potential Analysis
     11.7.1. By Country
     11.7.2. By Product Type
     11.7.3. By Application
  11.8. Middle East & Africa Non-Invasive Prenatal Testing Demand Share Forecast, 2019-2026
12. Competition Landscape
  12.1. Global Non-Invasive Prenatal Testing Market: Market Share Analysis
  12.2. Non-Invasive Prenatal Testing Distributors and Customers
  12.3. Non-Invasive Prenatal Testing Market: Competitive Dashboard
  12.4. Company Profiles (Details: Overview, Financials, Developments, Strategy)
     12.4.1. Genesis Genetics Natera, Inc. Centogene N.V. Illumina, Inc. Eurofins LifeCodexx GmbH MedGenome Labs Ltd. F. Hoffmann-La Roche Ltd. Myriad Women’s Health, Inc.
Segments Covered in the Report
The global non-invasive prenatal testing market has been segmented on the basis of

Gestation Periods
  • 0-12 Weeks
  • 13-24 Weeks
  • 25-36 Weeks
Risk Types
  • High & Average Risk
  • Low Risk
Methods
  • Ultrasound Detection
  • Biochemical Screening Tests
  • Cell-free DNA in Maternal Plasma Tests
Technology
  • NGS
  • Array Technology
  • PCR
  • Others
Products
  • Consumables & Reagents
  • Instruments
End-users
  • Hospitals & Clinics
  • Diagnostic Laboratories
Regions
  • Asia Pacific
  • North America
  • Latin America
  • Europe
  • Middle East & Africa
Key Players
  • Genesis Genetics
  • Natera, Inc.
  • Centogene N.V.
  • Illumina, Inc.
  • Eurofins LifeCodexx GmbH
  • MedGenome Labs Ltd.
  • F. Hoffmann-La Roche Ltd.
  • Myriad Women’s Health, Inc.
  • Progenity, Inc.
  • Qiagen
  • Laboratory Corp. of America Holdings
  • Quest Diagnostics, Inc.

Some of the major players competing in the global non-invasive prenatal testing market are Genesis Genetics; Natera, Inc.; Centogene N.V.; Illumina, Inc.; Eurofins LifeCodexx GmbH; MedGenome Labs Ltd.; F. Hoffmann-La Roche Ltd.; Myriad Women’s Health, Inc.; Progenity, Inc.; Qiagen; Laboratory Corp. of America Holdings; and Quest Diagnostics, Inc.

To differentiate themselves and solidify their market share, major players are widening their test portfolio. Companies are now concentrating on introducing new products to maintain and expand their market share. Illumina released an updated version of its VeriSeq NIPT in June 2019, allowing for the diagnosis of a wider spectrum of chromosomal interactions with birth defects. Moreover, Natera announced the extension of coverage for its Panorama offering in April 2020, which was made available to all targeted patients, regardless of age or illness.

Non-invasive Prenatal Testing Market By Key Players

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