Segments - Intravenous Anticoagulants Market By Type (Heparin, Fondaparinux, Direct Thrombin Inhibitors), Application (Unfractionated Heparin (UFH), Low Molecular Weight Heparin (LMWH), Fondaparinux, and Direct Thrombin Inhibitors), End use (Hospital, Clinics, and Ambulatory Centers), and Regions (North America, Europe, Asia Pacific, Latin America, and Middle East & Africa) - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 2023-2031
The Global Intravenous Anticoagulants Market was estimated at USD 13,479.9 Million in 2022 and is anticipated to reach USD 22,682.0 Million by 2031, expanding at a CAGR of 5.96% during the forecast period.
Intravenous anticoagulants are medications that are administered intravenously to prevent blood clots. It is given to patients who are at high risk of developing clots, to decrease the chances of the appearance of serious conditions, including strokes and heart attacks.
A blood clot is a barrier produced by the blood itself to stop bleeding from the site of an injury. However, if the blood clots do not stick to the site of an injury or form in the bloodstream, it proves to be extremely dangerous.
These get stuck in a small blood vessel if clots are large. When that small vessel is in a critical part of the body such as the heart, brain, or lungs, these clots obstruct the blood flow of these organs, which are necessary to survive.
The demographic profile of a population, particularly the geriatric population, is one of the important factors influencing the intravenous anticoagulants market. The high chance or incidence of blood clots in elder people influences the demand for intravenous anticoagulants.
The rapid surge in the number of coronary artery bypass surgeries and related conditions among the aging population significantly influences the demand for intravenous anticoagulants.
For instance, according to the American Health Association, around 89.4% of males and 90.8% of females aged 80 and above had cardiovascular diseases (CVD) in 2021. Additionally, the National Library of Medicine (NLM) stated that many older patients are frequently undergoing adult cardiac surgery.
Rising incidence of cardiovascular diseases across the globe is expected to drive the intravenous anticoagulants market during the forecast period.
For instance, according to a finding from the World Heart Federation, the number of CVD deaths is anticipated to increase from an estimated 18.9 million in 2020 to more than 22.2 million in 2030 and 32.3 million in 2050.
Anticoagulants are important in cardiovascular therapy and parenteral anticoagulants are widely used in cardiology, mostly in acute situations. Unfractionated heparin (UFH) is used in open heart CABG, open heart valve replacement/repair, transcatheter valve replacement, carotid artery, transmyocardial revascularization, aneurysm surgery, left atrial appendage, atrial fibrillation ablation, and percutaneous coronary intervention (PCI). Thus, the rising CVD diseases are anticipated to boost the demand for intravenous anticoagulants.
Incidence of venous thromboembolism (VTE) is very common in cancer patients, as they are at higher risk of developing VTE compared to the general population. Multiple overlapping thrombotic & hemostatic pathophysiological pathways and several risk factors that are specific to this patient population increase the risk of VTE.
Therefore, it requires a daily injection of low-molecular-weight heparin (LMWH) for 6 months instead of an oral anticoagulant. Thus, the rising burden of cancer incidence and mortality rate at a rapid pace across the globe is anticipated to boost the intravenous anticoagulant market during the forecast period.
For instance, according to data published by the Pan American Health Organization in 2023, the cancer burden is projected to increase by around 60% over the next two decades. Moreover, the global number of cancer cases is anticipated to reach 30 million by 2040, with the high increase occurring in low- and middle-income countries.
Strict regulations on intravenous anticoagulants, including drug price regulation, quality control, and FDA rules and regulations, affect the market.
For instance, in India, the Drug Price Control Order (DPCO) are issued under the Essential Commodities Act, 1955. In addition to that all dosages which are mentioned in the National List of Essential Medicines (NLEM) will be under price control.
The National Pharmaceutical Pricing Authority (NPPA) is the price regulator of India. Price controls over pharmaceuticals are often arbitrary and unpredictable, which makes it challenging for the pharmaceutical industry to do business in India.
The Union Ministry of Health issued a notification to ensure the quality of drugs, which requires conducting bio-equivalence (BE) studies for generic drugs that are approved by the State FDA.
The development of NOAC reversal agents to increase the safety of patients creates a lucrative opportunity in the intravenous anticoagulant market. The non-vitamin K antagonist oral anticoagulants (NOACs), such as dabigatran inhibit thrombin, and betrixaban, apixaban, rivaroxaban, and edoxaban inhibit coagulation factor Xa.
However, NOACs clinical studies were conducted without antidotes and major bleeding issues are mostly found in patients who receive NOACs and are no worse than those patients who treated with a vitamin K antagonist.
The report on the global Intravenous Anticoagulants market includes an assessment of the market, trends, segments, and regional markets. Overview and dynamics have also been included in the report.
Attributes |
Details |
Report Title |
Intravenous Anticoagulants Market – Global Industry Analysis, Size, Share, Growth, Trends, and Forecast |
Base Year |
2022 |
Historic Data |
2016-2021 |
Forecast Period |
2023–2031 |
Segmentation |
By Type (Heparin, Fondaparinux, Direct Thrombin Inhibitors), By Application (Unfractionated Heparin (UFH), Low Molecular Weight Heparin (LMWH), Fondaparinux, and Direct Thrombin Inhibitors), By End use (Hospital, Clinics, and Ambulatory Centers), |
Regional Scope |
Regions (North America, Europe, Asia Pacific, Latin America, and Middle East & Africa) |
Report Coverage |
Company Share, Market Analysis and Size, Competitive Landscape, Growth Factors, and Trends, and Revenue Forecast |
Key Players Covered |
Abbott, AstraZeneca, B. Braun SE, Baxter International Inc., Bayer AG, Bristol-Myers Squibb Company, Fresenius SE & Co. KGaA., GSK plc, Johnson & Johnson, Novartis AG, Pfizer Inc., and Viatris Inc. |
Based on Type, the market is segmented into heparin, fondaparinux, and direct thrombin inhibitors. The heparin segment is expected to hold a considerable share of the market during the forecast, as heparin is often preferred as an intravenous anticoagulant in specific clinical situations when compared to fondaparinux and direct thrombin inhibitors such as argatroban or bivalirudin.
On the basis of Application, the market is fragmented into unfractionated heparin (UFH), low molecular weight heparin (LMWH), fondaparinux, and direct thrombin inhibitors. The open-heart CABG subsegment held the significant share of the market in 2022. UFH has a rapid onset of action, making it suitable for immediate anticoagulation during open-heart surgery.
For instance, according to the University of Alabama at Birmingham, nearly 350,000 CABG surgeries are performed annually in the US, which is boosting the demand for Unfractionated Heparin (UFH). All these factors are expected to drive the open-heart CABG sub-segment during the forecast period.
In terms of End-use, the market is classified as hospitals, clinics, and ambulatory centers. The hospitals segment is anticipated to expand at a significant CAGR during the forecast period, owing to the rising cardiovascular diseases, which leads to a rise in cardiac surgery procedures.
For instance, according to research by Teleflex Incorporated, a US-based medical device company, more than 600,000 open cardiothoracic procedures are performed in the US each year.
Based on regions, the market is fragmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America accounted for a significant share of the market in 2022. The intravenous anticoagulants market in North America is influenced by several factors that contribute to its growth.
The growth of the market in the US is attributed to the growing number of cardiovascular diseases in the country. Treatment for cardiovascular diseases often includes immediate anticoagulation therapy to prevent further clotting and complications.
As per the American Heart Association, cardiovascular disease (CVD) remains the leading cause of death in the US, accounting for 928,741 deaths in 2020.
In 2023, Fresenius Kabi entered into a license agreement with Formycon AG to commercialize a proposed Ustekinumab biosimilar candidate.
In 2023, Pfizer Inc. acquired a biologics drug substance manufacturing facility in Sanford, North Carolina from Abzena.
In 2022, Viatris Inc. sold its international biosimilars business to Biocon Biologics.
In 2022, Fresenius Kabi entered into a partnership with Bio-Manguinhos and Bionovis for the production and supply of the company’s adalimumab biosimilar, IDACIO in Brazil.
In 2019, Fresenius Kabi Introduces Heparin Sodium Injection, USP Simplist Prefilled Syringe in 5,000 USP units per 0.5 mL dose.
In 2021, GSK Plc. secured approval from European Medicines Agency for its intravenous and subcutaneous Benlysta (belimumab) in combination with background immunosuppressive therapies for the treatment of adult patients with active lupus nephriti.
In-depth Analysis of the Global Intravenous Anticoagulants Market
Historical, Current, and Projected Market Size in Terms of Value
Potential & Niche Segments and Regions Exhibiting Promising Growth Covered
Industry Drivers, Restraints, and Opportunities Covered in the Study
Recent Industry Trends and Developments
Competitive Landscape & Strategies of Key Players
Manufacturers operating in the global Intravenous Anticoagulants market are Abbott, AstraZeneca, B. Braun SE, Baxter International Inc., Bayer AG, Bristol-Myers Squibb Company, Fresenius SE & Co. KGaA., GSK plc, Johnson & Johnson, Novartis AG, Pfizer Inc., and Viatris Inc.
Market players are pursuing strategies such as acquisitions, product launches, collaborations, and geographic expansion to leverage untapped opportunities in the global Intravenous Anticoagulants market.
Additional company profiles can be provided on request. For a discussion related to the above findings, click Speak to Analyst
Factors such as competitive strength and market positioning are key areas considered while selecting top companies to be profiled.
Increasing Incidence Of Cardiovascular Diseases is the factors expected to drive the market growth during the forecast period.
According to this Growth Market Reports report, the global Intravenous Anticoagulants market is likely to register a CAGR of 5.96% during the forecast period 2023-2031, with a projected valuation of USD ~22,682.0 million by the end of 2031.
Factors such as Population Demographics is analyzed in the final report.
Major manufacturers include Abbott, AstraZeneca, B. Braun SE, Baxter International Inc., Bayer AG, Bristol-Myers Squibb Company, Fresenius SE & Co. KGaA., GSK plc, Johnson & Johnson, Novartis AG, Pfizer Inc., and Viatris Inc.
The pandemic had a significant impact on various markets, including the Intravenous Anticoagulants market. The COVID-19 Treatment Guidelines Panel (the Panel) advised patients with COVID-19 who are receiving anticoagulant or antiplatelet therapy for underlying illnesses to continue taking these drugs until severe bleeding occurs or other contraindications exist.
In addition to market size (in US$ Million), impact of key regulations, pricing analysis, is provided in the final report.
The forecast year considered for the global Intravenous Anticoagulants market report is 2031.
The base year considered for the global Intravenous Anticoagulants market report is 2022. The complete analysis period is 2016 to 2031, wherein, 2016 to 2021 are the historic years, and the forecast is provided from 2023 to 2031.