High-performance Liquid Chromatography (HPLC) Market Size [2031]

Report Description

High-performance Liquid Chromatography (HPLC) Market Outlook 2031

The Global High-performance Liquid Chromatography (HPLC) Market size was USD 4.45 Billion in 2022 and is likely to reach USD 7.4 Billion by 2031, expanding at a CAGR of 5% during 2023–2031. The market growth is attributed to the increasing importance of HPLC tests for drug approvals and the popularity of hyphenated techniques.

Increasing popularity of hyphenated techniques is expected to fuel the high-performance liquid chromatography market. HPLC separates the part of a mixture through a partition, adsorption, ion exchange, or size exclusion mechanism. The HPLC system is useful in the analysis of organic, inorganic, and biological molecules. The launch of various liquid chromatography methods for the development systems and support software increases the usage and productivity of HPLC systems.

• In May 2023, 3CHI a leading innovator in the hemp and cannabis industry introduced Delta Specific (D-SPEC). It is a ground-breaking HPLC testing method for modern hemp products. While testing the method development, it runs into the tens of thousands of dollars, 3CHI company is giving away D-SPEC for free to crime and cannabis labs to bring much-needed standardization to the industry.

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The market report finds that the COVID-19 pandemic fueled the high-performance liquid chromatography market, due to the increasing adoption of HPLC systems for the development of vaccines, therapeutics, and reliable diagnostics methods for the diseases. Liquid chromatography is coupled with mass spectrometry which is used to quantify remdesivir in the blood plasma of COVID patients and provides data on its efficacy as a treatment for severe acute respiratory syndrome coronavirus 2 (SARS CoV-2). However, the strict lockdown imposed by the governments and the shutdown of companies hindered the HPLC market. During the pandemic, companies faced several difficulties and insufficient funding for the research academic institutes which hampers the market.

Impact of Artificial Intelligence in the High-performance Liquid Chromatography (HPLC) Market

Artificial intelligence (AI) technologies are expected to boost the high-performance liquid chromatography market during the forecast period. AI has the potential to play a powerful role in automating HPLC, from optimizing methods to remote monitoring and auto diagnostic capabilities. In addition, researchers have employed AI techniques such as Hammerstein-Weiner (HW), support vector machine (SVM), and multi-layer perception (MLP) for predicting the qualitative properties of an anti-Alzheimer agent using a high-pressure liquid chromatography technique.

High-performance Liquid Chromatography (HPLC) Market Dynamics

Major Drivers

Increasing adoption of HPLC techniques in the pharmaceutical industries and analysis is expected to drive the high-performance liquid chromatography market during the forecast period. In the pharmaceutical industries, HPCL techniques are used to prevent, treat, or cure disease. Further, it is used to test the products and detect the raw materials that are used to make quantitative and qualitative analyses in the pharmaceutical industries and analysis. The crucial role that HPLC plays in quality control, drug development, stability testing, regulatory compliance, and pharmacokinetic studies increases the adoption of HPLC in the pharmaceutical industry.

• In October 2021, Novasep launched Hipersep Process M, an HPLC system designed for the purification of pharmaceutical molecules such as oligonucleotides, peptides, insulin, and other synthetic molecules. The Hiipersep Process M is customized with modular options to respond to customer-specific needs.

Existing Restraints

High cost of HPLC is expected to hinder the high-performance liquid chromatography market in the coming years. HPLCs are expensive to set up and regular maintenance is required, with high costs for equipment, consumables, and columns. It is a complex technique that needs specialized knowledge and training to operate correctly, which hampers the HPLC market.

Emerging Opportunities

Rising research & development activities for the HPLC technologies are expected to create lucrative opportunities for the market players. Analytical use of the technologies for medical research, forensics, and other applications has created opportunities for the development of HPLC systems. Fully-portable and hand-carried systems are developed by the companies and such developments represent breakthrough opportunities for product development to increase the adoption of the technologies. For instance,

• The Axcend Focus LC is a breakthrough, fully portable HPLC system that is hand-carried anywhere. This system is small enough to be easily placed near the sample source and powerful enough to use in any state-of-the-art laboratory.

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Scope of High-performance Liquid Chromatography (HPLC) Market Report

The market report includes an assessment of the market trends, market segments, and regional markets. Overview and dynamics have also been included in the report.

High-performance Liquid Chromatography (HPLC) Market Segment Insights

Product Segment Analysis

Based on product, the high-performance liquid chromatography market is divided into (consumables, accessories, instruments, and software. The consumables segment is further segmented into the filters, columns, tubes, and others. The instruments segment is further divided into pumps, detectors, HPLC systems, and others.

The instruments segment is expected to expand at a significant pace during the projection period, owing to the availability of advanced detectors and the rising dominance of integrated HPLC systems. The segment growth is further attributed to the high demand for efficient and accurate analytical instruments for quality control, research, and drug development purposes. Increasing innovative development of HPLC technologies such as high resolution, improved detector sensitivity, enhanced automation, and faster analysis times which increases the adoption of instruments segment in the market.

The consumables segment is anticipated to hold a key share of the market in the coming years, due to the high demand for columns, filters, syringes, tubes, and others. HPLC consumables are a crucial part of any HPLC laboratory and it is powerful analytical technologies that are used to identify, separate, and quantify components in several mixtures. To ensure accurate results and reliable performance, it is important to invest in quality HPLC consumables to meet the specific requirements of the lab. The segment growth is further attributed to the growing significance of filtration technologies for the protection of HPLC columns for any particulate contaminants and the increasing improvements in column chemistries and packing materials.

• In July 2023, Phenomenex Inc., a leader in the research and manufacture of advanced technologies, launched Luna Polar Pesticides HPLC Column which features a proprietary phase that efficiently separates anionic and cationic pesticides from underivatized feed, food, fast conditioning, air, and water samples, and delivers vigorous ionic pesticide analysis.

Application Segment Analysis

In terms of application, the global market is segregated into diagnostic, clinical research, forensics, and others. The clinical research segment is projected to register a considerable CAGR during the forecast period, due to the increasing biopharmaceutical research & development, the expanding landscape of clinical trial activities, and high demand for analytical technologies. HPLC is the method that is used to separate components within a substance such as blood. By quantifying and identifying these components, researchers potentially find clearer biomarkers for disease which allows for earlier diagnosis and intervention for further patients. Chromatography is the most important separation technique that is used to detect and quantitatively measure pharmaceutical drugs and chemical components.

The diagnostic segment is anticipated to account for a major market share in the coming years, as it is used for the quantification and identification of biomarkers crucial in the earlier diagnosis of diseases. HPLC offers a superior option for analysis of metabolites and it is used in the analysis of vitamin D and HbA1c hemoglobin, owing to its low coefficient of variation and reproductivity. The segment market growth is further attributed to the growing prevalence of chronic diseases and the high need for diagnostic technologies and applications of HPLC.

• According to the World Health Organization (WHO), chronic disease (noncommunicable diseases) affects around 41 million individuals each year. Around 17 million individuals die from NCD before the age of 70 each and 86% of these are premature deaths occur in low- and middle-income countries each year.

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End-user Segment Analysis

On the basis of end-user, the high-performance liquid chromatography market is segmented into academic & research institutions, pharmaceutical & biotechnology companies, and others. The pharmaceutical & biotechnology companies’ segment is expected to register a robust growth rate during the forecast period. HPLC is considered a crucial tool in a variety of pharmaceutical applications such as checking purity, evaluating formulations, and monitoring changes, owing to process adjustments. An important application of HPLC is maintaining the uniformity of active pharmaceutical ingredients (API). By conducting quantitative analysis of certain molecules, it is possible to verify the accurate dosage of active ingredients. In terms of QA/QC testing, HPLC is helpful for ensuring essential quality characteristics such as potency, consistency of content, identification and measurement of impurities, and the quality and identity of raw materials.

Regional Analysis

In terms of region, the global high-performance liquid chromatography (HPLC) market is classified as Asia Pacific, North America, Latin America, Europe, and Middle East & Africa. North America is expected to dominate the market during the projection period, owing to the high demand for clinical diagnostic applications and the high adoption of advanced techniques and systems in manufacturing HPLC. In the US, several government research organizations use HPLC technology to analyze the exact components in a drug mixture. For instance,

• According to the report published by the United States Environmental Protection Agency (EPA), in May 2023 the environmental sampling and analytical methods (ESAM) provide procedures for the determination of free carbonyl compounds in several matrices by derivatization with 2, 4-dinitrophenylhydrazine (DNPH). The method utilizes HPLC with ultraviolet (UV) detection to identify and quantitate the target analytes.

The market in Asia Pacific is anticipated to expand at a rapid pace in the coming years, due to the high growth in the pharmaceutical & biotechnology sectors in China and India. The regional market growth is further attributed to the high potential for clinical research due to the availability of a large pool of potential. Increasing investment in research & development activities in the healthcare systems as well as high need to advance the healthcare facilities.

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