Chromatography Resins Market Share, Industry Analysis [2031]

Report Description

Chromatography Resins Market Outlook 2031

The global chromatography resins market size was USD 2.45 Billion in 2022 and is likely to reach USD 3.95 Billion by 2031, expanding at a CAGR of 6.9% during the forecast period, 2023–2031. Market growth is attributed to the rising usage of chromatography resins and increasing demand for the pharmaceutical & biotechnology industry.

High usage of chromatography techniques in the pharmaceutical & biotechnology industry is expected to drive the market. Chromatography plays a crucial role in the purification of biomolecules such as nucleic acid, proteins, and carbohydrates, in the biotechnology industry. The purification of biomolecules is an essential step in the development of biopharmaceuticals, gene therapy, and other biotech products. The chromatography methods are precise, accurate, quick, and easy and they are widely used for regular quality control examination of medicines in bulk and pharmaceutical dosage forms.

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The market report finds that the COVID-19 pandemic fueled the chromatography resins market, due to the increasing development of vaccines by governments all over the world. Increasing research & development activities in the production of drug testing and vaccines, especially in the biopharmaceutical industry. However, the shutdown of companies and research institutes and the strict lockdown imposed by the governments hampered the market.

Chromatography Resins Market Dynamics

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Major Drivers

Increasing demand for biosimilars is expected to boost the chromatography resins market during the forecast period. Bio-separation techniques used in the manufacturing of biosimilar antibodies are improving the adoption of chromatography resins. Biosimilars are utilized for rheumatoid arthritis, anemia, cancer, infectious disorders, type 1 & 2 diabetes, psoriasis, post-menopausal osteoporosis, and hormonal disorder treatments. These applications have increased the usage of chromatography resins in the development and manufacturing of economic drugs.

Existing Restraints

High initial costs of setting up the chromatography process is expected to hamper the market in the coming years. The cost of chromatography resins is high due to the complex manufacturing process and the high degree of specialization required to produce them. The resins are made from a variety of materials including dextran, agarose, and silica, which are costly to produce and refine.

Affinity chromatography is the most expensive chromatography method, as it often highly purifies protein and is manufactured before the target protein, which is expected to hinder the market.

Emerging Opportunities

Increasing technological advancements and research & development activities are expected to create lucrative opportunities for the market players. The need for appropriate and effective chromatography resins is increasing, owing to the development of novel chromatography techniques including fast high-performance liquid chromatography (HPLC) and fast protein liquid chromatography (FPLC).

However, increasing demand for chromatography in drug development is expected to boost the market. Resins are available to capture, separate, polish, and analyze of wide range of biomolecules, and streamline process development from drug discovery through clinical trials and bioproduction.

Scope of Chromatography Resins Market Report

The market report includes an assessment of the market trends, market segments, and regional markets. Overview and dynamics have also been included in the report.

Chromatography Resins Market Segment Insights

Type Segment Analysis

Based on type, the chromatography resins market is divided into natural, synthetic, and inorganic. The natural segment is expected to expand at a significant pace during the projection period, due to the increasing consumption of naturally derived products, low nonspecific binding, and paper chromatography in various industries. Natural chromatography resins are made from natural polymers such as agarose, cellulose, and dextran.

These resins are used in several industry sectors food & beverages, pharmaceutical & biotechnology, and others, which is expected to boost the segment in the market. The synthetic segment is anticipated to hold a key share of the market in the coming years, as they are widely used in ion-exchange chromatography.

The segment growth is further attributed to the high demand for synthetic chromatography resins from biopharmaceutical companies. Synthetic chromatography resins are made from synthetic polymers and are increasingly being used more than the natural to increase production figures.

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Technique Segment Analysis

In terms of technique, the global market is segregated into hydrophobic interaction chromatography, ion exchange chromatography, affinity chromatography, size exclusion chromatography, and others. The ion exchange chromatography (IEX) segment is projected to register a considerable CAGR during the forecast period, owing to the growing emphasis on drug discovery by contract research organizations (CROs) and pharmaceutical companies.

IEX media contain positively or negatively charged functional groups covalently bound to a solid support, yielding either a cation or anion exchanger. Some of the common media used include agarose, polystyrene, cellulose, polymethacrylate, and polyacrylamide. IEX is widely used in various industrial applications such as biotechnology, fermentation, and food and clinical research.

The affinity chromatography (AC) segment is anticipated to account for a major market share in the coming years, due to the high demand for protein purification and the increasing usage of monoclonal antibodies. Increasing demand for AC technologies in the separation of the mixture of compounds, enzyme assays, removal of impurities in the purification process, and other applications improves the high adoption of this technology among end-users.

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• In March 2020, Avantor, Inc. launched a recombinant Protein A affinity chromatography resin that is used to purify antibodies during monoclonal antibody (mAbs) production. New high-purity resin developments bioprocessing and bring choice and efficiencies to mAbs production workflow protocols and processes. Monoclonal antibody drugs treat a wide variety of clinical indications for cancer treatments, mAbs enlist natural immune system functions to fight the disease.

End-User Segment Analysis

On the basis of end-user, the market is segmented into food & beverage, pharmaceutical & biotechnology, and others. The pharmaceutical & biotechnology segment is expected to register a robust growth rate during the forecast period, due to the high usage of chromatography to manufacture drugs and the increasing consumption of resins in the pharmaceutical process.

The segment growth is further attributed to the rising use of monoclonal antibodies in therapeutic areas such as tuberculosis diagnostics, oncology, and autoimmune diseases and a large number of CROs and contract manufacturing organizations (CMOs) in the pharmaceutical sector.

• In January 2023, Astera Bioseparations Ltd, acquired Delta Precision Ltd, a premium manufacturer of advanced chromatography columns for the pharmaceutical and biotechnology industries. This strategic acquisition allows Astera Bio to expand its product offering to include a full range of high-performance chromatography columns for biomanufacturing complementing and strengthening the company's existing portfolio of bioprocessing resins, prepacked single-use columns, and reusable columns.

The food & beverage segment is projected to hold a large share of the market in the coming years, owing to the increasing consumer preference for natural food products and rapid advancements in science and technology. The IEX technique is a creative and active field in the food & beverages industry, which plays a crucial role in the development of the food industry.

The ion exchange resins are used for water treatment, dealkalization, and softening in the food industry. The food & beverage industry utilizes these resins to ensure product safety, quality control, and adherence to regulatory standards.

Regional Analysis

In terms of region, the global chromatography resins market is classified as Asia Pacific, North America, Latin America, Europe, and Middle East & Africa. North America is expected to dominate the market during the projection period, owing to the high demand for drug discovery to control diseases worldwide and growth in pharmaceutical and biotechnology companies.

Emerging countries such as the US is increasing in the pharmaceutical industry, due to the rise in healthcare expenditure, aging population, and growing diseases. The regional market growth is further attributed to the increasing chromatography advanced technologies that are used for diagnosing purposes and food analytics owing to the rising consumption of chromatography resins.

The market in Asia Pacific is anticipated to expand at a rapid pace in the coming years, due to the expansion of the pharmaceutical industry in emerging countries such as India, China, and South Korea. The regional market is attributed to a large number of CROs and CMOs and high economic growth.

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